Fig. 9. Representation of the tight, adherens junctions within the endothelial cells in our model of blood-brain barrier. Tightly joined and functional endothelial cells under normal atmospheric gas pressure. Opening of the paracellular pathway under SH and IH, and alteration in P-gp - BCRP expression/activity.BCRP: breast cancer related protein, P-gp: P-glycoprotein.